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KMID : 0613820060160040659
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Journal of Life Science
2006 Volume.16 No. 4 p.659 ~ p.663
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Growth-inhibitory Effects of the Plocamium telfairiae Extracts on Cancer Cells
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Kim Ju-Young
Cha Mi-Ran
Hwang Ji-Hwan
Park Hae-Ryong
Choi Sun-Uk
Hwang Yong-Il
Choi Byeong-Dae
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Abstract
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The extracts of Plocamium telfairiae using several solvents with different polarities were prepared and their growth inhibitory effects were examined on the human cancer cells. We investigated the cytotoxic effects of P. telfairiae extracts on HT-29 cells by the MTT reduction assay and examining the morphological change under the inverted microscope. Among three extracts, the methanol extract showed the strongest inhibitory effect on the growth of HT-29 cells. The methanol extract was further fractionated sequentially with n-hexane, diethyl ether, ethyl acetate, and aqueous for purifying crude methanol extract. The n-hexane layer among the fractioned layers showed remarkable inhibitory activity on the growth of HT-29 cells. Moreover n-hexane layer showed the notable growth inhibition effects with a dose-dependent manner against SW620, HeLa, and MCF-7 cells as well as HT-29 cells. These results indicated that P. telfairiae extracts may be contained bioactive materials with inhibitory effect on the growth of human cancer cells.
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KEYWORD
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Plocamium telfairiae, growth inhibition, anticancer, cancer cells
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